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Record W1984532367 · doi:10.1159/000130452

A quantitative analysis of Colcemid-induced chromosomal nondisjunction in Chinese hamster cells in vitro

2008· article· en· W1984532367 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueCytogenetics and Cell Genetics · 2008
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicDNA Repair Mechanisms
Canadian institutionsUniversity of ManitobaChildren's Hospital of Winnipeg
Fundersnot available
KeywordsNondisjunctionColcemidBiologyMonosomyChinese hamsterGeneticsAneuploidyChromosomeChromosome 21TrisomyMolecular biologyKaryotypeIn vitroCell cultureGene

Abstract

fetched live from OpenAlex

A quantitative analysis of Colcemid-induced chromosomal nondisjunction in cultured Chinese hamster cells is presented. Chromosome counts were made immediately following nondisjunction and also determined for colonies arising after treatment. Nondisjunction of a single chromosome occurred randomly. When two or more chromosomes were involved, the process was nonrandom and appeared to be independent of chromosome size. The frequency distribution of the extra chromosomes in single and multiple trisomic clones which survived Colcemid treatment was nonrandom, although every group could be involved. Monosomy appeared in 0.8 % of the surviving clones. Although monosomy for each chromosome grouping was observed immediately after nondisjunction, only monosomics involving the smaller chromosomes proliferated beyond this stage to form a colony.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.008
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.015
GPT teacher head0.248
Teacher spread0.233 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it