Is caspase‐dependent apoptosis only cell differentiation taken to the extreme?
Bibliographic record
Abstract
The benefits of apoptosis for a multicellular organism are obvious and fit the current dogma that the maintenance and viability of such organisms are dependent on the selective elimination of unneeded or deleterious cell types. However, self destruction at the level of the individual cell defies the most basic precepts of biology (sustaining life). If apoptosis is viewed through this construct then one question becomes paramount, i.e., why would an individual cell and its progeny develop, retain, or evolve a mechanism the sole purpose of which is to eliminate itself? In consideration of such a paradox, it is reasonable to postulate that prospective apoptotic pathways coevolved with and or were co-opted from another basic cell function(s) that did not involve the death of the cell per se. In the following article, we present the hypothesis that the conserved biochemical pathways of apoptosis are integral components of terminal cell differentiation and it is the time of engagement and activity level of these pathways that ultimately determines the choice between cell death or cell maturation.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".