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Record W1985103305 · doi:10.1136/bmj.323.7321.1085

Report clears researcher who broke drug company agreement

2001· article· en· W1985103305 on OpenAlexaboutno aff
David J. Spurgeon

Bibliographic record

VenueBMJ · 2001
Typearticle
Languageen
FieldMedicine
TopicBiomedical Ethics and Regulation
Canadian institutionsnot available
Fundersnot available
KeywordsGovernment (linguistics)MedicineFamily medicineDrug CompanyConfidentialityWaiverPolitical scienceLawManagement

Abstract

fetched live from OpenAlex

A new report has urged Canada's federal government to do more to curb attempts by pharmaceutical companies to influence the conduct and publication of clinical studies carried out by researchers into their products. The report, commissioned by the Canadian Association of University Teachers, follows a four year dispute at the Toronto Hospital for Sick Children, centring on attempts by a drug company to prevent publication of results of a trial that were unfavourable in relation to one of its products. The dispute began after researcher Dr Nancy Olivieri decided to break a confidentiality agreement with Apotex, a Toronto based pharmaceutical company that was sponsoring her research. She published results critical of the drug deferiprone, which she was testing in young patients with thalassaemia, in the New England Journal of Medicine (1998;339:417-23). Dr Olivieri, former head of the hospital's haemoglobinopathy programme, was threatened with legal action by Apotex and also removed from her hospital post, though she …

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.054
metaresearch head score (Gemma)0.155
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesResearch integrity
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Editorial · Consensus signal: none
Teacher disagreement score0.947
Threshold uncertainty score0.284

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0540.155
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.002
Bibliometrics0.0020.001
Science and technology studies0.0130.004
Scholarly communication0.0140.008
Open science0.0040.007
Research integrity0.0530.037
Insufficient payload (model declined to judge)0.0310.017

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.077
GPT teacher head0.401
Teacher spread0.325 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

Study designNot applicable
Domainnot available
GenreEditorial

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations10
Published2001
Admission routes1
Has abstractyes

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