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Record W1985838762 · doi:10.1002/iub.270

The path to RNA editing in plant mitochondria: The Halifax chapter

2009· review· en· W1985838762 on OpenAlexafffundabout
Michael W. Gray

Bibliographic record

VenueIUBMB Life · 2009
Typereview
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicPhotosynthetic Processes and Mechanisms
Canadian institutionsDalhousie University
FundersMedical Research CouncilCanadian Institutes of Health ResearchMedical Research Council Canada
KeywordsRNA editingProtein subunitMitochondrionBiologyRNAAlternative oxidaseGeneGeneticsMolecular biologyBiochemistry

Abstract

fetched live from OpenAlex

A single C/T difference between gene and cDNA within the 5'-untranslated region of the wheat mtDNA-encoded cox2 (cytochrome oxidase subunit 2) sequence catalyzed the discovery of C-to-U RNA editing in plant mitochondria by a group at Dalhousie University in Halifax, Nova Scotia [Covello and Gray, (1989) Nature 341, 662-666]. Editing of codons specifying essential copper-binding ligands in the Cox2p Cu(A) site provided additional insights about the amino acid residues comprising this site, as well as illustrating the functional importance of editing in wheat mitochondria. Further investigations of RNA editing in plant mitochondria led to the subsequent discovery of a case of mitochondrion-to-nucleus gene (cox2) transfer in soybean, mediated by reverse transcription of edited cox2 mRNA.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.998
Threshold uncertainty score0.011

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0010.001
Science and technology studies0.0000.001
Scholarly communication0.0010.002
Open science0.0010.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0030.003

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.021
GPT teacher head0.282
Teacher spread0.261 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations3
Published2009
Admission routes3
Has abstractyes

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