ON MODELING OF LIVING ORGANISMS USING HIERARCHICAL COARSE-GRAINING ABSTRACTIONS OF KNOWLEDGE
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
High throughput technologies such as gene expression microarray, ChIP-chips, siRNA and protein arrays and high throughput mass spectrometry are enabling an ever increasing amount of data becoming available about DNA, RNA, proteins, metabolites as well as biological pathways and networks. The knowledge embedded in this data deluge needs to be recast in forms that lend themselves to analysis with the expectation of developing analytical instruments to gain insight and answer questions about life and living organisms. The powers of abstraction and model building are fundamental to the quest of making sense of the biological complexity embedded in these biological and clinical datasets. The modeling of living organisms is explored with a proposed framework for model representation of biological complexity. The principal foundational assumption of the proposed modeling philosophy recognizes the symbiotic relationship between information and energy flows, required for the transformation of matter, as a fundamental organizing force underlying the observable nature of living organisms. The use of the concept of regularities to refer to complexity of structure, function and dynamics alike provides a unified approach to the reasoning about the integration of knowledge representations of varying natures and scales of granularities. The application of the proposed modeling approach is illustrated in broad qualitative terms for the human organism.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it