Seroepidemiology of Hepatitis E Virus Infection in Mennonites in Mexico
Bibliographic record
Abstract
BACKGROUND: The seroepidemiology of hepatitis E virus (HEV) infection in Mennonites has not been studied. We aimed to determine the seroprevalence of anti-HEV IgG antibodies in Mennonites in Durango, Mexico, and to compare it with the seroprevalence in general population in rural Durango. The socio-demographic, clinical and behavioral characteristics of Mennonites associated with HEV seropositivity were also investigated. METHODS: We performed a case-control study to determine the frequency of anti-HEV IgG antibodies in 150 Mennonites (mean age 38.40 ± 15.53 years old) and 150 age- and gender-matched non-Mennonites controls using an enzyme-linked immunoassay. We used a standardized questionnaire to obtain the socio-demographic, clinical and behavioral characteristics of the Mennonites. RESULTS: Anti-HEV IgG antibodies were detected in 10 (6.7%) of 150 Mennonites and in 61 (40.7%) of 150 controls. Seroprevalence of anti-HEV IgG antibodies was significantly lower in Mennonites than in controls (odds ratio (OR) = 0.009; 95% confidence interval (CI): 0.0006 - 0.15; P < 0.000001). Logistic regression of socio-demographic and behavioral characteristics of Mennonites showed that HEV seropositivity was only associated with increasing age (OR = 1.05; 95% CI: 1.00 - 1.09; P = 0.03). While sex, birth place, residence, educational level, socio-economic status, occupation, animal contacts, foreign travel, frequency of eating away from home, consumption of raw or undercooked meat, type of meat consumed, consumption of unpasteurized milk or untreated water, and consumption of unwashed raw vegetables or fruits were not associated with HEV seropositivity. None of the Mennonites suffered from clinical hepatitis. CONCLUSIONS: RESULTS DEMONSTRATE: 1) serological evidence of HEV exposure in Mennonites; however, Mennonites have a lower seroprevalence of HEV antibodies than controls from the rural general population; 2) seroprevalence in Mennonites increased with age. Further studies with a larger sample size to determine more contributing factors for HEV infection in Mennonites are needed.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.047 | 0.106 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.002 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; both teacher heads agree on what is shown here.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".