Flash photolysis of 4-diazoisochroman-3-one in aqueous solution. Hydration of the carbene produced by loss of nitrogen and ketonization of the enol hydration product
Bibliographic record
Abstract
Flash photolysis of 4-diazoisochroman-3-one in aqueous solution resulted in loss of nitrogen and transient production of the α-carbonylcarbene 3-ketoisochroman-4-ylidene, the hydration of which generated a short-lived species that was identified as the enol isomer of the lactone, 4-hydroxyisochroman-3-one. This assignment is supported by x-ray crystallographic determination of the structure of the final lactone product, by the shape of the rate profile for ketonization of the enol intermediate to the lactone, and by solvent isotope effects on, and the form of acid–base catalysis of, the ketonization reaction. Copyright © 2000 John Wiley & Sons, Ltd. Additional material for this paper is available from the epoc website at http://www.wiley.com/epoc
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".