Lupus cardiomyopathy: a reversible form of left ventricular dysfunction
Bibliographic record
Abstract
Myocarditis has been reported to be a common postmortem finding of systemic lupus erythematosus (SLE) patients. However, most case reports on SLE cardiomyopathy have not found myocarditis on biopsy. Stress-related cardiomyopathies result in reversible left ventricular (LV) dysfunction. The purpose of this study is to characterize the nature and course of LV dysfunction in SLE patients. We evaluated a large cohort of SLE patients hospitalized at Cedars Sinai Medical Center between 28 August 2001 and 30 October 2010. Patients were included in the study that met American College of Rheumatology criteria for SLE, had an erythrocyte sedimentation rate and high sensitivity C-reactive protein performed, and had an echocardiogram with ejection fraction (EF) <45% during index hospitalization. Admission data, medications, and echocardiograms were reviewed. Five-hundred and twenty-six SLE patients were surveyed, of which 15 patients met all study inclusion criteria with LVEF ranging from 15 to 45%, mean 33 ± 9.8%, Twelve of 15 patients demonstrated a reversal of acute cardiomyopathy, showing an improvement in LVEF from 10 to 40%, mean 23.4 ± 9%. Twelve patients had generalized LV hypokinesis. Two patients underwent coronary angiography and had no obstructive coronary lesions. One patient also underwent cardiac biopsy, which did not show any evidence of myocarditis. Of the three patients whose cardiomyopathy did not reverse, all died due to their underlying medical illness. This is the first report to describe a reversible cardiomyopathy in SLE patients. The pattern of wall motion abnormalities and its reversibility is more indicative of a stress-related cardiomyopathy syndrome than being the result of myocarditis.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".