Changes in the G Gamma- and A Gamma-Globin mRNA Components of Fetal Hemoglobin during Human Development
Bibliographic record
Abstract
To determine the postnatal developmental changes in (G)gamma- and (A)gamma-globin mRNAs of HbF, blood samples were obtained from 28 pre-term infants born at < or = 33 weeks of gestation (27.9 +/- 2.5), 9 term-born infants and 26 adults. Adult samples were used to determine the relationship between the levels (G)gamma- and (A)gamma-mRNAs of HbF and the-158 (C-->T) variation in the promoter region of the (G)gamma-globin gene. The results showed that (G)gamma-globin mRNA to total gamma-globin mRNAs remained around 66% (66.2 +/- 4) until the 44 week of postconceptual age when a change in the (G)gamma- and (A)gamma-globin mRNA proportions occurred. The immature red cells of adults had a range of (G)gamma-globin mRNA to total gamma-globin mRNAs varying from 20 to 74% (53.1 +/- 16.9). The high levels of (G)gamma-globin mRNA to total gamma-globin mRNAs are associated with the presence of a -158 (C-->T) polymorphism. The gene frequency of polymorphism was 0.32.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".