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Record W1990813498 · doi:10.1126/science.1251788

A chromosome-based draft sequence of the hexaploid bread wheat ( <i>Triticum aestivum</i> ) genome

2014· article· en· W1990813498 on OpenAlexafffund
Klaus Mayer, Jane Rogers, Jaroslav Doležel, Curtis Pozniak, Kellye Eversole, Catherine Feuillet, Bikram Gill, Bernd Friebe, Adam J. Lukaszewski, Pierre Sourdille, Takashi R. Endo, Marie Kubaláková, Jarmila Číhalíková, Zdeňka Dubská, Jan Vrána, Romana Šperková, Hana Šimková, Melanie Febrer, Leah Clissold, Kirsten McLay, Kuldeep Singh, Parveen Chhuneja, Nagendra Kumar Singh, Jitendra P. Khurana, Eduard Akhunov, Frédéric Choulet, Adriana Alberti, Valérie Barbe, Patrick Wincker, Hiroyuki Kanamori, Fuminori Kobayashi, Takeshi Itoh, Takashi Matsumoto, Hiroaki Sakai, Tsuyoshi Tanaka, Yasunari Ogihara, Hirokazu Handa, P. Ron Maclachlan, Andrew Sharpe, Darrin Klassen, David Edwards, Jacqueline Batley, Odd-Arne Olsen, Simen R. Sandve, Sigbjørn Lien, Burkhard Steuernagel, Brande B. H. Wulff, Mario Cáccamo, Sarah Ayling, Ricardo H. Ramírez-González, Bernardo Clavijo, Jonathan Wright, Matthias Pfeifer, M. Spannagl, Mihaela Martis, Martin Mascher, Jarrod Chapman, Jesse Poland, Uwe Scholz, Kerrie Barry, Robbie Waugh, Daniel S. Rokhsar, Gary J. Muehlbauer, Nils Stein, Heidrun Gundlach, Matthias Zytnicki, Véronique Jamilloux, Hadi Quesneville, Thomas Wicker, Primetta Faccioli, Moreno Colaiacovo, A. M. Stanca, Hikmet Budak, Luigi Cattivelli, Natasha Glover, Lise Pingault, Etienne Paux, Sapna Sharma, R. Appels, M. Bellgard, Thomas Nußbaumer, Kai Christian Bader, Hélène Rimbert, Shichen Wang, R. E. Knox, Andrzej Kilian, Michaël Alaux, Françoise Alfama, L.J. Couderc, Nicolas Guilhot, Claire Viseux, Mikaël Loaec, Beat Keller, Sébastien Praud

Bibliographic record

VenueScience · 2014
Typearticle
Languageen
FieldAgricultural and Biological Sciences
TopicWheat and Barley Genetics and Pathology
Canadian institutionsUniversity of Saskatchewan
FundersBayer CropScienceNorges ForskningsrådAgence Nationale de la RechercheTürkiye Bilimsel ve Teknolojik Araştırma KurumuFrance AgriMerBundesministerium für Bildung und ForschungMinistry of Agriculture, Forestry and FisheriesOffice of ScienceGrains Research and Development CorporationInternational Center for Agricultural Research in the Dry AreasKansas Wheat CommissionEuropean Molecular Biology LaboratoryGenome PrairieBiotechnology and Biological Sciences Research CouncilInstitut National de la Recherche AgronomiqueArcadia FundRural and Environment Science and Analytical Services DivisionDeutsche ForschungsgemeinschaftMinistry of Agriculture - SaskatchewanGenome CanadaDirectorate for Biological SciencesJoint Genome InstituteGrantová Agentura České RepublikyWestern Grains Research FoundationU.S. Department of AgricultureEuropean CommissionU.S. Department of Energy
KeywordsBiologyPolyploidGenomeGenePloidyGeneticsChromosomeCommon wheatWhole genome sequencingGenome evolution

Abstract

fetched live from OpenAlex

An ordered draft sequence of the 17-gigabase hexaploid bread wheat (Triticum aestivum) genome has been produced by sequencing isolated chromosome arms. We have annotated 124,201 gene loci distributed nearly evenly across the homeologous chromosomes and subgenomes. Comparative gene analysis of wheat subgenomes and extant diploid and tetraploid wheat relatives showed that high sequence similarity and structural conservation are retained, with limited gene loss, after polyploidization. However, across the genomes there was evidence of dynamic gene gain, loss, and duplication since the divergence of the wheat lineages. A high degree of transcriptional autonomy and no global dominance was found for the subgenomes. These insights into the genome biology of a polyploid crop provide a springboard for faster gene isolation, rapid genetic marker development, and precise breeding to meet the needs of increasing food demand worldwide.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.010
Threshold uncertainty score0.034

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0020.004
Science and technology studies0.0010.000
Scholarly communication0.0010.000
Open science0.0010.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0100.010

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.018
GPT teacher head0.218
Teacher spread0.201 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1,638
Published2014
Admission routes2
Has abstractyes

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