Cardiovascular Disease Risk Profile in Japanese Midlife Migraineurs
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Background: Migraine is a common disabling disorder. A significant association between migraine and cardiovascular disease (CVD) has been reported in European and North American population. Little is known about CVD risk factors in Asian migraineurs. We aimed to clarify CVD risk profile of midlife migraineurs in Japan. Methods: A total of 596 subjects (409 women and 187 men) were diagnosed as migraine with aura (MA) and without aura (MO), according to the ICHD-II criteria. CVD risk factors were analyzed on body mass index, west circumference / height, smoking index , blood pressure (BP), serum l ipid levels , f asting blood sugar, hemoglobin A 1C , C-reactive protein, and a family history of CVD or stroke. Those factors were compared between migraineurs and 599 healthy controls matched by age and sex. Results: Mean age (SD) of migraineurs was 44.6 (9.4) years, 44.3 (9.4) in women and 45.2 (9.3) in men. Mean duration of migraine (SD) was 16.7 (11.4) years, 18.7 (12.2) in women and 13.3 (9.1) in men. Frequency and score of migraine attacks were higher significantly in women compared to men (P less than 0.01). As compared to controls, systolic and diastolic BP was significantly increased in female and male migraineurs (P less than 0.01). High-density lipoprotein cholesterol was decreased (P less than 0.01), and total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) were increased in sera of female and male migraineurs (P less than 0.01). Serum triglyceride levels were higher in male migraineurs (P less than 0.01). Migraineurs had higher frequency of relatives with CVD or stroke (P less than 0.01). With respect to migraine subtypes, MA and MO sufferers significantly elevated BP (P less than 0.05) and serum levels of TC and LDL-C (P less than 0.01). Conclusions: The present study indicated unfavorable CVD risk factors of BP, serum lipid levels and a family history of CVD or stroke in middle-aged migraineurs. The similarity of CVD risk profile was first confirmed between Japanese and Western migraineurs. doi:10.4021/jnr82w
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.005 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.002 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it