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The co-translocation of ERp57 and calreticulin determines the immunogenicity of cell death

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

Canadian funderA Canadian agency funded it. The work may carry no Canadian affiliation at all.

No Canadian affiliation. An affiliation-only frame, the usual design, would never have seen this work. It is one of the works that make the case for inverting the frame.

Classifier prediction

metacan-v1-d91a1de5be90

Predictions imitate two machine teachers. Scores are not calibrated prevalence probabilities.

Classifier candidate
ObservationalBench or experimental
Classifier consensus
ObservationalBench or experimental
Teacher imitation scores

Codex

Bench or experimental0.802
Observational0.414
Other design0.001
Not applicable0.000
Theoretical or conceptual0.000
Meta-analysis0.000
Science and technology studies0.000
Simulation or modelling0.000
Metaresearch0.000
Research integrity0.000
Randomized trial0.000
Qualitative0.000
Case report0.000
Scholarly communication0.000
Non-randomized trial0.000
Meta-epidemiology (narrow)0.000
Bibliometrics0.000
Open science0.000
Systematic review0.000
Meta-epidemiology (broad)0.000

Gemma

Bench or experimental0.915
Observational0.281
Simulation or modelling0.001
Science and technology studies0.000
Not applicable0.000
Theoretical or conceptual0.000
Research integrity0.000
Non-randomized trial0.000
Randomized trial0.000
Metaresearch0.000
Meta-analysis0.000
Qualitative0.000
Case report0.000
Meta-epidemiology (narrow)0.000
Meta-epidemiology (broad)0.000
Open science0.000
Bibliometrics0.000
Scholarly communication0.000
Systematic review0.000

Machine scores (provisional)

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Opus teacher head0.009
GPT teacher head0.220
Teacher spread
0.212 how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Abstract

The exposure of calreticulin (CRT) on the plasma membrane can precede anthracycline-induced apoptosis and is required for cell death to be perceived as immunogenic. Mass spectroscopy, immunofluorescence and immunoprecipitation experiments revealed that CRT co-translocates to the surface with another endoplasmic reticulum-sessile protein, the disulfide isomerase ERp57. The knockout and knockdown of CRT or ERp57 inhibited the anthracycline-induced translocation of ERp57 or CRT, respectively. CRT p…

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