Antiluminal Transport of L-Arginine and L-Leucine Following Microinjections in Peritubular Capillaries of the Rat
Bibliographic record
Abstract
In order to determine the degree of exchange diffusion between the tubular cells of the rat kidney and the tubular lumen, microinjections of labeled amino acids and inulin have been carried out in peritubular capillaries. The animals were undergoing mannitol diuresis. Fractionated urinary collections were made from the ureters of both kidneys after each microinjection in order to determine the content in radioactivity. L-Arginine-14C and inulin-3H or L -leucine-3H and inulin-14C were injected. Our data show that: (1) Inulin excretion follows a similar pattern in both the control and the experimental kidney. (2) The amino acid excretion is almost as large in the control kidney as in the experimental one. However, the quantity found in the experimental kidney is always greater, this supplementary fraction being 2.0 ± 0.44% of the injected dose. (3) In experiments carried out under a perfusion of unlabeled amino acids, the supplementary fraction excreted by the experimental kidney increases slightly to 3.9 ± 1.03%. Our results indicate that the renal tubular cells are permeable from the basal membrane towards the tubular lumen; however, the fluxes in this direction are not as large as suggested by previous in vitro studies.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".