Factors Related to Six-minute Walk Test Results in Adults with Cerebral Palsy
Bibliographic record
Abstract
As adults with cerebral palsy (CP) grow older, there is an increased risk for their walking capacity to decrease which could lead to less social participation, poorer health and decreased quality of life. Although the six-minute walk test (6MWT) has demonstrated reliability for this group, it has rarely been used to assess their functional walking capacity and its physiologic correlates are not known. PURPOSE: To describe in adults with CP, relationships between the 6MWT distance and selected physiologic and related measures. METHODS: Sixteen men and 4 women (21-41 yrs) with CP performed the 6MWT during which time oxygen consumption (VO2) and heart rate (HR) were assessed. The following were also measured; HR, blood pressure and VO2 at rest, height, weight, gross motor function (Gross Motor Function Measure (GMFM)), the preferred walking speed over 5 m, and isometric knee extensor strength (hand-held dynamometer). Pearson's correlation coefficients were used to define the relationships between the 6MWT distance and each of the independent variables. Step-wise regression analysis assessed the inter-relationships between the 6MWT and factors that were significant (p < 0.05) in the correlational analysis. RESULTS: The variables significantly correlated (r) to the 6MWT distance were; resting HR (−0.54), minute 6 VO2 per kg body mass (0.45), minute 6 VO2 per meter walked (−0.78), the GMFM total score (0.89), the GMFM-D score related to standing (0.91), the GMFM-E score related walking (0.94), walking speed over 5 m (0.89), and knee extensor strength on the dominant (0.60) and non-dominant (0.66) sides. Step-wise regression showed that together, the GMFM-E score, minute 6 VO2 per kg body mass, and the 5 m walking speed explained 90% of the variance in the 6MWT distance. CONCLUSION: For adults with CP, the 6MWT is especially related (positively) to gross motor function skills associated with walking. These skills and high energy expenditure during minute 6 of the test explain most of the variance in 6MWT results. Further research is needed to determine, for this population, if the 6MWT tracks changes in walking capacity over time and if improved gross motor skills related to walking result in improved walking capacity as assessed by this test. Supported by CIRRIS and the Laval University Research Chair in Cerebral Palsy
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.004 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".