Internalization of serotonin 5‐HT<sub>1A</sub>autoreceptors as an imaging biomarker of antidepressant response
Bibliographic record
Abstract
Abstract Serotonin (5‐hydroxytryptamine, 5‐HT) and its various receptors are involved in numerous CNS functions. Among the currently known 5‐HT receptors, the 5‐HT 1A receptor is the best characterized subtype. It is tightly implicated in the pathogenesis of mood disorders, notably in depression, and thus represents an important target for drug therapy. Binding to 5‐HT 1A receptors can be visualized and quantified by positron emission tomography (PET), facilitating the translation from animal research to man. Using the 5‐HT 1A radiotracer [ 18 F]MPPF, recent PET studies in cat and human have provided evidence that internalization of 5‐HT 1A autoreceptors is amenable to in vivo neuroimaging at the very onset of specific serotonin reuptake inhibitor (SSRI) administration. The in vivo detection of this phenomenon in human is promising in terms of clinical management, particularly as an early biomarker of responsiveness to SSRI treatment. However, several questions are still pending regarding the correlation between 5‐HT 1A internalization at the onset of the treatment and the ensuing therapeutic efficacy. WIREs Membr Transp Signal 2012,1:239–245. doi: 10.1002/wmts.11 For further resources related to this article, please visit the WIREs website .
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".