Retinal Vessels Thrombosis as Onset Manifestation of Systemic Sclerosis: 3 Clinical Cases
Bibliographic record
Abstract
To the Editor: Posterior ocular segment involvement in systemic sclerosis (SSc) is rare. To the best of our knowledge, the retinal vascular occlusion presenting at onset of SSc has never been reported in the literature. We describe 3 cases of patients with retinal thrombosis without apparent risks of ocular disease, followed by fully SSc typical manifestations. Of note, all 3 patients fulfilled the new 2013 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) classification criteria for the diagnosis of SSc at onset, while the previous 1980 ACR criteria were satisfied long after. In SSc, the most frequent ocular manifestations involve anterior segment, such as eyelid skin fibrosis and keratoconjunctivitis sicca. Posterior segment involvement is less common, and findings similar to those observed in arterial hypertensive retinopathy, such as cotton wool spot, optical disc edema, and hemorrhages, have been reported1,2. Nevertheless, abnormal ocular findings are frequently detected by fluorescein angiography (FA), and posterior segment microvessel damage and pigment epithelium layer atrophy are shown in up to 50% of patients with … Address correspondence to Dr. F. Iannone, Rheumatology Unit, Policlinico, Piazza G. Cesare 11, 70124 Bari, Italy. E-mail: florenzo.iannone{at}uniba.it
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.004 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.002 | 0.002 |
| Science and technology studies | 0.002 | 0.001 |
| Scholarly communication | 0.002 | 0.002 |
| Open science | 0.002 | 0.002 |
| Research integrity | 0.009 | 0.003 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".