Overnight variations in IL-6 in synovial fluid and plasma in patients with active rheumatoid arthritis
Bibliographic record
Abstract
Aim: To investigate for the first time overnight variations in absolute values and patterns of synovial fluid IL-6, and other proinflammatory cytokines including IL-1β and TNF, and to relate them to blood concentrations of cytokines and cortisol in rheumatoid arthritis. Patients & methods: Six people with active rheumatoid arthritis and large knee effusions who had received no recent glucocorticoids were admitted overnight. Blood and synovial fluid samples were obtained at 13 time points between 21:00 and 10:00. Results: The geometric mean synovial fluid IL-6 concentration increased significantly from 1483 pg/ml at 21:00 to 5084 pg/ml at 08:00 (repeated measures ANOVA p < 0.001). The geometric mean plasma IL-6 and cortisol concentrations increased significantly overnight. In a random coefficient model including data from all participants, the estimated mean synovial fluid IL-6 value began to rise approximately 6 h before the estimated mean plasma IL-6, which in turn began to rise approximately 3 h before ...
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".