Cryptosporidiosis in Juvenile Bearded Dragons (Pogona vitticeps): Effects of Treatment with Paromomycin
Bibliographic record
Abstract
Abstract Cryptosporidia are regularly detected during routine coprologic screenings of healthy bearded dragons ( Pogona vitticeps ). The objectives of this study were to histologically characterize infections by Cryptosporidium sp. in bearded dragons and to evaluate the effect of paromomycin treatment in bearded dragons infected by Cryptosporidium sp. Ten four-month-old bearded dragons were initially infected with an isolate of Cryptosporidium sp. that was acquired from a naturally infected adult bearded dragon. The infection was confirmed in both groups by coprologic examination. The infected animals were then divided into two groups: a treatment group and a control group. Oral treatment with paromomycin began seven weeks after infection in the treatment group using the following regimens: 100 mg/kg q 24 h for seven days; then twice a week for six weeks; and 360 mg/kg q 48 h during the final 10 days of the study. Cryptosporidia were only detected in the intestinal lumens in the non-treated lizards. None of the treated lizards showed evidence of cryptosporidia excretion on either coprologic or histopathological examination. This finding suggests that the treatment with paromomycin was effective. All bearded dragons from both groups remained fully asymptomatic. Nevertheless, because of the highly contagious nature of these parasites and the pathogenicity to species that may be housed in the vicinity of asymptomatic carriers, and because a possible pathogenic effect for immunocompromised bearded dragons cannot be ruled out, treatment of infected bearded dragons remains a recommended practice.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".