Calcium-dependent potassium channels in the heart: clarity and confusion
Bibliographic record
Abstract
This editorial refers to ‘Critical roles of a small conductance Ca2+-activated K+ channel (SK3) in the repolarization process of atrial myocytes’ by X.-D. Zhang et al. , pp. 317–325, this issue and ‘Overexpression of KCNN3 results in sudden cardiac death’ by S. Mahida et al. , doi:10.1093/cvr/cvt262 and ‘Overexpression of KCNN3 results in sudden cardiac death’ by S. Mahida et al ., doi:10.1093/cvr/cvt269. Small-conductance Ca2+-activated K+ (SK) channels are widely expressed throughout the body. After initial dismissal of a functional role for SK channels in the heart,1 a series of elegant studies from the Chiamvimonvat laboratory rekindled interest,2,3 as did subsequent work suggesting that tachypaced rabbit pulmonary veins have enhanced SK channel trafficking to the cell membrane that accelerates repolarization.4 The field really got a boost from GWAS evidence, suggesting that variants in the KCNN3 gene encoding SK isoform 3 (SK3) channels are associated with the risk of atrial fibrillation (AF) in man.5 Questions remain, however, about the functional role that SK currents play in cardiac electrophysiology. Recent studies of SK channels in native tissues have provided conflicting results. Two investigations …
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.007 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.009 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; both teacher heads agree on what is shown here.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".