Molecular Characterization of Major Allergens Associated with Baker's Asthma in Wheat Flour
Bibliographic record
Abstract
Many allergens belong to the defense response proteins, which are produced when the plant is under various stresses. The amino acid sequences of the main wheat flour allergens associated with baker's asthma were analyzed in this study. The gene sequences of monomeric (WMAI), dimeric (WDAI), tetrameric (WTAI, which contains 1 WTAI-CM2 unit, 2 CM3 units and 1 CM16 unit) α-amylase inhibitor and fructose bisphosphate aldolase from wheat, barley and rye were obtained and characterized. Compared with other main allergens, it was shown that the fifteen proteins have a common conserved cysteine skeleton and the presence of CC and CX1-4C motifs, which are not usually found in other non-allergenic proteins. Most of these allergens have putative N-glycosylation sites. Protein structure either mediated through di-sulfide bonds or through higher order protein-protein interactions, plays a critical role in the allergenicity of allergens. It was also found that the same protein family allergens did not share similar 3D structures. With regard to the characterized sequences as well as protein structures of allergens, it is obvious that the flour proteins that have been implicated as important wheat seed allergens causing baker's asthma are complex but have some specific related behavioral traits.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".