Abstract P4-11-07: Quantitative Coronary Angiography Findings of Patients Who Received Previous Breast Radiotherapy
Bibliographic record
Abstract
Abstract Purpose: To compare the coronary angiographic findings, between patients who had previous left sided breast radiotherapy (RT) and those who had right sided RT. Methods: Between 1995 and 2009, 12696 patients who underwent curative RT for breast cancer in Princess Margaret Hospital were screened to check if they had a post-RT coronary angiogram. Two cardiologists, blinded to treatment, assessed all angiograms and measured the percentage of stenotic lesions and the mean diameter of each segment of the left anterior descending artery (LAD) and the right coronary artery (RCA) using Quantitative Coronary Angiography (QCA). Results: Ninety-one patients were included, 49 and 42 patients had left sided RT and right sided RT respectively. The median time from RT to coronary angiogram was 4.4 years (range: 22 days - 16.9 years). Nineteen patients (39%) in the left sided RT group and 17 (40%) in the right sided RT group needed coronary revascularization (percutaneous coronary intervention or by-pass surgery). The LAD territory was revascularized in 14 (29%) and 11 (26%) patients respectively. The degree of stenoses and mean vessel diameter were not significantly different between the two groups. Table 1: Quantitative The proportion of patients who developed clinically significant stenoses of coronary arteries were not statistically different between the two groups. Table 2: Patiens In 32 patient who had coronary angiograms >5 years after breast RT (16 left-sided and 16 right-sided), the only statistically significant finding (P<0.05) was marginally narrower mid RCA segments among those who had right sided RT: 2.52 mm versus 2.92 mm (P = 0.039). Conclusions: Left sided breast RT did not increase the risk of premature coronary artery disease as compared with right sided RT. However, with the limitation of short duration between radiotherapy and coronary angiogram, late development of coronary artery stenoses 10-15 years after left sided RT can not be excluded. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr P4-11-07.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.006 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".