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Record W1995928670 · doi:10.1016/j.jaci.2009.10.059

Mutations in STAT3 and diagnostic guidelines for hyper-IgE syndrome

2010· article· en· W1995928670 on OpenAlexafffund
Cristina Woellner, E. Michael Gertz, Alejandro A. Schäffer, Macarena Lagos, Mario Perro, Erik‐Oliver Glocker, Maria Cristina Pietrogrande, Fausto Cossu, José Luis Franco, N Matamoros, Barbara Pietrucha, Edyta Heropolitańska–Pliszka, Mehdi Yeganeh, Mostafa Moin, Teresa Español, Stephan Ehl, Andrew R. Gennery, Mario Abinun, Anna Bręborowicz, Tim Niehues, Sara Şebnem Kılıç, Anne Junker, Stuart E. Turvey, Alessandro Plebani, Berta Sánchez, Ben-Zion Garty, Claudio Pignata, Caterina Cancrini, Jiří Litzman, Özden Sanal, Ulrich Baumann, Rosa Bacchetta, Amy P. Hsu, Joie Davis, Lennart Hammarström, E. Graham Davies, Efrem Eren, Peter D. Arkwright, Jukka S. Moilanen, Dorothee Viemann, Sujoy Khan, László Maródi, Andrew J. Cant, Alexandra F. Freeman, Jennifer M. Puck, Steven M. Holland, Bodo Grimbacher

Bibliographic record

VenueJournal of Allergy and Clinical Immunology · 2010
Typearticle
Languageen
FieldImmunology and Microbiology
TopicImmunodeficiency and Autoimmune Disorders
Canadian institutionsBC Children's HospitalUniversity of British Columbia
FundersNational Cancer InstituteNational Institute of Allergy and Infectious DiseasesMedical Research CouncilEuropean Society for ImmunodeficienciesHungarian Scientific Research FundMinistry of Education, Culture, Sports, Science and TechnologyEuropean CommissionBursa Uludağ ÜniversitesiU.S. Department of Health and Human ServicesNational Institutes of HealthVetenskapsrådetChildren's Hospital FoundationCanadian Institutes of Health ResearchImmune Deficiency Foundation
KeywordsSTAT3Immunoglobulin EPrimary immunodeficiencyMedicineAntibodyImmunologyBiologyGeneGeneticsImmune system

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.008
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.004
Threshold uncertainty score0.012

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.008
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0040.001
Science and technology studies0.0010.001
Scholarly communication0.0010.001
Open science0.0020.001
Research integrity0.0040.003
Insufficient payload (model declined to judge)0.0010.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.034
GPT teacher head0.343
Teacher spread0.309 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations319
Published2010
Admission routes2
Has abstractno

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