Oral exposure of male and female mice to formulations of organophosphorous pesticides: congenital malformations
Bibliographic record
Abstract
Birth outcome was studied in pre-partum litters of mice exposed to oral doses of organophosphorous pesticides at low and high concentrations before mating. Exposed and unexposed pregnant dams were delivered by Caesarean section 1 day before partum, the fetuses were collected, counted and weighed, and the numbers of resorptions were recorded. Live litter sizes were non-significantly higher in all the exposed groups compared with the control group. The numbers of resorptions were significantly higher in all the exposed groups than in the comparison groups. The incidence of intra-uterine growth retardation was significantly higher in all the exposed groups than in the comparison groups. The incidences of congenital malformations were significantly higher in the exposed groups than in one or more of the comparison groups for the defects of the ears, eyes, jaws, brain, and tongue in all the exposed groups. Low set microtia, cataract or open eyelids, microcephaly or anencephaly, maxillary or mandibular hypoplasia, and protruding tongue were observed in all groups, but the numbers were significantly higher in the exposed groups compared with one or more of the comparison groups. Curled or missing tail and intra-auricular septal or intra-ventricular septal defects were observed in higher numbers in the groups in which both the males and the females were exposed than in the comparison groups. Male:female sex ratios were significantly higher in the groups in which males only and females only were exposed.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".