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Record W1997224430 · doi:10.2310/7200.2006.023

How to Randomize

2006· review· en· W1997224430 on OpenAlexvenueno aff
Andrew J. Vickers

Bibliographic record

VenueJournal of the Society for Integrative Oncology · 2006
Typereview
Languageen
FieldMathematics
TopicStatistical Methods in Clinical Trials
Canadian institutionsnot available
FundersNational Cancer Institute
KeywordsRandomizationRestricted randomizationMedicineRandomized controlled trialMedical physicsSurgery

Abstract

fetched live from OpenAlex

Randomized trials are an important method for deciding whether integrative oncology therapies do more good than harm. Many investigators do not pay sufficient attention to randomization procedures, and several studies have shown that only a fraction of trial reports describe randomization adequately. The purpose of randomization is to prevent selection bias: randomization procedures must therefore ensure that researchers are unable to predict the group to which a patient will be randomized until the patient is unambiguously registered on study; moreover, researchers must be unable to change a patient's allocation after the patients are registered. The use of telephone randomization and opaque envelopes has been suggested as a good randomization method, but both can be subverted. Randomization should be conducted either by a pharmaceutical company, which sends blinded medication to the hospital pharmacy, or by a secure, password-protected database system. Computer randomization can easily incorporate extensions of randomization, such as blocking, stratification, and minimization, which can help ensure balance between groups.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.135
metaresearch head score (Gemma)0.356
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch
Consensus categoriesnone
DomainCandidate signal: Methods · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Methods · Consensus signal: Methods
Teacher disagreement score0.865
Threshold uncertainty score0.712

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.1350.356
Meta-epidemiology (narrow)0.0030.002
Meta-epidemiology (broad)0.0050.005
Bibliometrics0.0040.003
Science and technology studies0.0020.004
Scholarly communication0.0040.005
Open science0.0020.002
Research integrity0.0060.008
Insufficient payload (model declined to judge)0.0450.018

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.617
GPT teacher head0.635
Teacher spread0.018 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

Study designNot applicable
DomainMethods
GenreMethods

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations150
Published2006
Admission routes1
Has abstractyes

Explore more

Same venueJournal of the Society for Integrative OncologySame topicStatistical Methods in Clinical TrialsFrench-language works237,207