Impact of adherence to statins on chronic heart failure in primary prevention
Bibliographic record
Abstract
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • The effects of statins may be beneficial to patients with chronic heart failure. • However, one question that has not yet been answered and that may clarify the role of statins in chronic heart failure (CHF) is whether statins prevent the development of CHF in patients with a low risk of cardiovascular disease (CVD)? WHAT THIS PAPER ADDS • The study results demonstrate that, in primary prevention, adherence to statins has a positive impact on CHF. • This study provides evidence of the potential role of statins in CHF. AIMS Statins are effective in the prevention of an atherosclerotic event, e.g. coronary artery disease and cerebrovascular disease. Patients at high risk of cardiovascular disease (CVD), such as chronic heart failure (CHF), might benefit from the effects of statin therapy. However, one question that has not yet been answered and that may clarify the role of statins in CHF is whether statins prevent the development of CHF in patients with a low risk of CVD. Our aim was to evaluate the impact of adherence to statins on the incidence of CHF. METHODS A cohort of 111 481 patients was reconstructed using the Régie de l'Assurance Maladie du Québec databases. Patients were eligible if they were between 45 and 85 years old, without CVD, and newly treated with statins between 1999 and 2004. A nested case–control design was used to study CHF. Every case of CHF was matched for age and duration of follow‐up in up to 15 randomly selected controls. The adherence level was measured by calculating the medication possession ratio. Rate ratios (RR) of CHF were estimated by conditional logistic regression adjusting for several covariables. RESULTS The mean patient age was 63 years, 49% had hypertension, 21% had diabetes and 41% were male. A high level of adherence to statins was associated with a reduction of CHF (RR 0.81; 0.71, 0.91). The risks associated with CHF were the development of CVD during follow‐up, being a social‐aid recipient, and suffering from hypertension, diabetes mellitus, or having a higher chronic disease score. CONCLUSION Our study indicates that better adherence to statins is associated with a reduced risk of CHF.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".