Ultrastructural Features of an Aldosterone-Secreting Adrenocortical Adenoma
Bibliographic record
Abstract
An aldosterone-secreting adrenocortical adenoma was removed by surgery from a 15-year-old boy who exhibited signs characteristic of Conn’s syndrome including hypertension, potassium depletion and increased aldosterone production rate. The neoplasm was found to consist mainly of clear cells by light microscopy. Ultrastructural investigations revealed that the neoplasm was composed chiefly of fasciculata cells characterized by mitochondria with vesicular cristae. Some mitochondria, however, possessed tubular cristae reminiscent of those occurring in zona glomerulosa cells. It appears that mitochondria are not rigidly static constituents of cells but they can change constantly in order to satisfy variations in functional need. Other ultrastructural features included accumulation of lysosomes and lipofuscin granules, an increase of the rough-surfaced endoplasmic reticulum membranes, lipid depletion, focal hypertrophy and dilatation of the Golgi sacculi, and a pronounced hypertrophy of the smooth-surfaced endoplasmic reticulum. The latter alterations were thought to represent the fine structural manifestations of enhanced cellular activity associated with increased production of aldosterone.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".