Developmental Timing of Activated erbB2 Expression Plays a Critical Role in the Induction of Mammary Tumors
Bibliographic record
Abstract
Mammary specific expression of the activated erbB2 in the mammary epithelium has been demonstrated to be a potent inducer of mammary carcinomas in number of different transgenic mouse models. Indeed we have recently shown that mammary epithelial specific activation of erbB2 under the transcriptional control of the endogenous erbB2 promoter is capable of inducing focal mammary tumors after a long latency period. To assess whether the developmental timing of expression of this allele would impact tumor formation we expressed the same erbB2 allele under the endogenous promoter in the germline of mice. Our recent report on these mice has revealed that mice expressing the activated erbB2 allele in the germline did not develop tumors although mice expressing an identical allele specifically in the mammary gland at equal levels developed tumors with a high penetrance. These recent reports are reviewed herein and taken together suggest that the developmental window of expression of a potent oncogene may impact tumorigenesis.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".