Fatty Acids and Exercise Affect Glucose Transport But Not Tumour Growth in F-344 Rats
Bibliographic record
Abstract
This study examined the effect of diet and exercise on tumour growth, and the effect of dietary fatty acids on glucose uptake. Male Fischer 344 rats were divided into 4 dietary groups and fed for 2 weeks. The diets were 5% (wt/wt) safflower oil, 10% safflower oil, 5% docosahexaenoic acid(DHA)-rich, and 10% DHA-rich. On Day 14 the animals were injected with rat fibrosarcoma tumour cells. After 3 days of tumour growth the animals in each diet group were divided into exercise and nonexercise groups. Exercise was achieved by voluntary wheel running. Dietary intake, body weight, tumour growth, and distance run were determined daily. Two weeks later the animals were euthanized and the following tissues were dissected out: tumour, liver, heart, epididymal fat pads, gastrocnemius, epitrochlearis, and soleus muscles. Glucose transport experiments were performed on the epitrochlearis and soleus muscles whereas phospholipid analysis was completed on the gastrocnemius muscle. We observed no effect of either diet or exercise on tumour growth. The glucose transport data demonstrates that short-term voluntary running can cause increased insulin-sensitive transport and that DHA may inhibit transport. DHA-containing diets were associated with increased oxidation products TBARM. In conclusion, exercise benefits on glucose disposal are maintained in tumour-bearing animals but are influenced by fat content and composition. High DHA diets may also increase oxidative damage in muscle through enhanced TBARM production.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".