Doubling the dose of inhaled corticosteroid for asthma exacerbations does not decrease subsequent use of systemic steroids
Bibliographic record
Abstract
▴ Harrison TW, Oborne J, Newton S, et al . Doubling the dose of inhaled corticosteroid to prevent asthma exacerbations: randomised controlled trial. Lancet2004;363:271–5 [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] This blinded trial with concealed randomisation compared doubling the dose of inhaled corticosteroid for 14 days with continuing the same dose when asthma symptoms or peak flow worsened in patients monitoring themselves daily at home. The 390 patients enrolled had been given oral corticosteroid or transiently doubled their inhaled corticosteroid dose in … [1]: {openurl}?query=rft.jtitle%253DLancet%26rft.stitle%253DLancet%26rft.aulast%253DHarrison%26rft.auinit1%253DT.%2BW.%26rft.volume%253D363%26rft.issue%253D9405%26rft.spage%253D271%26rft.epage%253D275%26rft.atitle%253DDoubling%2Bthe%2Bdose%2Bof%2Binhaled%2Bcorticosteroid%2Bto%2Bprevent%2Basthma%2Bexacerbations%253A%2Brandomised%2Bcontrolled%2Btrial.%26rft_id%253Dinfo%253Adoi%252F10.1016%252FS0140-6736%252803%252915384-6%26rft_id%253Dinfo%253Apmid%252F14751699%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1016/S0140-6736(03)15384-6&link_type=DOI [3]: /lookup/external-ref?access_num=14751699&link_type=MED&atom=%2Fthoraxjnl%2F59%2F4%2F346.atom [4]: /lookup/external-ref?access_num=000188361400008&link_type=ISI
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".