Guest-Mediated Access to a Single DNA Nanostructure from a Library of Multiple Assemblies
Bibliographic record
Abstract
We present a method in which a small molecule template is used to access a single DNA nanostructure from a library of multiple assemblies. DNA building blocks 2 and 2 ‘, in which two identical DNA arms branch from a fully rigid organic vertex, were synthesized and their self-assembly was found to generate a small dynamic library of products. The small molecule Ru(bpy) 3 2+ was found to provide access to a single member from this library (i.e., square 5 ) and was also found to re-equilibrate each other already formed member into 5 quantitatively. The use of a small molecule to access a single DNA assembly from many possible combinations introduces an additional level of control in DNA construction. In addition, the ability of this template to transform the other members into the same single product provides a built-in correction mechanism that helps ensure the integrity of the construction process, even when “errors” are made. We apply this approach to predictably generate periodic 1D DNA fibers extending over tens of microns, using two trifunctional symmetrical DNA building blocks that otherwise assemble into ill-defined oligomeric networks.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".