Effect of Reduced Calcium on Lysophosphatidylcholine-Induced Cardiac Arrhythmias
Bibliographic record
Abstract
Lysophosphatidylcholine (LPC) had recently been shown to accumulate in the ischemic heart and was demonstrated to be arrhythmogenic in perfused hearts. The present study was designed to examine the effects of calcium and verapamil on LPC-induced arrhythmias. Rat hearts were perfused through the aorta with oxygenated Krebs-Henseleit buffer at 37 degrees C. The occurrence of ventricular fibrillation was dependent on the LPC concentration and perfusion time. In subsequent experiments, each heart was perfused with a buffer containing 20 microM LPC for 3 min and was followed with a 10 min washout period. Ventricular fibrillation occurred in all 8 control experiments. When the Ca2+ concentration was reduced to half, only 3 out of 8 hearts fibrillated. In the presence of 0.2 mg/1 of verapamil, 7 out of 9 hearts fibrillated, and the time to fibrillation was not increased significantly by verapamil. These results suggest that calcium may be important in LPC-induced arrhythmias, and this effect is not significantly attenuated by the Ca2+ antagonist, verapamil.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".