Neisserial Opa Proteins: Impact on Colonization, Dissemination and Immunity
Bibliographic record
Abstract
The pathogenic Neisseria sp. encode a family of phase-variable and antigenically distinct Opa proteins that allow bacterial attachment to virtually every cell type encountered during infection. Some Opa variants bind cell surface-expressed heparan sulfate proteoglycans, including members of the syndecan family of receptors, and extracellular matrix proteins such as fibronectin and vitronectin. Other variants bind members of the carcinoembryonic antigen family of cellular adhesion molecules. Depending on the Opa variant(s) expressed, these receptor interactions can allow neisserial entry and transcellular transcytosis across polarized epithelial cell monolayers, entry into endothelial cells, suppression of lymphocyte function and/or bacterial engulfment and killing by neutrophils. Recent advances in our understanding of how these Opa protein-mediated interactions influence the host cellular response are discussed in the context of their impact on various stages of neisserial infection.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".