Contribution of glutamate receptors to brain-derived neurotrophic factor-induced elevation of intracellular Ca2+levels
Bibliographic record
Abstract
In the present study, acute effects of brain-derived neurotrophic factor (BDNF) on intracellular calcium concentration ([Ca2+]i) in cultured visual cortical neurons were investigated. We examined specifically whether pharmacological blockade of glutamatergic receptors interfered with effects of BDNF on [Ca2+]i. We found that blockade of N-methyl-D-aspartate (NMDA) receptors significantly reduced the number of BDNF-responsive neurons, while inhibition of metabotropic glutamate receptors (mGluR) completely prevented the effect of BDNF. By contrast, blockade of alpha-amino-3-hydroxy-5-methyl-4-isoxasole propionic acid (AMPA) receptors did not affect the BDNF-induced increase of [Ca2+]i. Our results thus suggest that glutamate-mediated excitatory pathways are involved in the BDNF-induced rise of [Ca2+]i in visual cortical neurons, and that both mGluR and NMDA receptors play a critical role in this event.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".