Distinct roles for the cellular inhibitors of apoptosis proteins 1 and 2
Bibliographic record
Abstract
The cellular inhibitor of apoptosis proteins 1 and 2 (cIAP1 and cIAP2) are members of a highly conserved and critically important family of inhibitor of apoptosis proteins (IAPs) that function to mitigate both intrinsic and extrinsic death signalling. Their conserved mechanism of action in vitro relies on competitive inhibition of caspase activity. In recent years, however, ubiquitin ligase activity within cIAP1/2 has been shown to have a central role in regulating NF- κ B signalling and programmed cell death through the ubiquitylation of key components of TNF receptor complexes. Owing to the importance of NF- κ B signalling in a variety of pathologies, cIAP1/2 have become desirable drug targets and there is thus a strong rationale for studying how cIAP1/2 expression is regulated in these contexts. Although these paralogous proteins function in a redundant manner, their context-dependent differential expression provide for non-redundant roles. Here, we will focus on evaluating possible distinct functions for cIAP1 in specific cellular settings where it acts as the dominant player and review recent advances in our understanding of how cIAP1 expression can be regulated at the post-transcriptional level.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.002 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".