PREDICTION OF THE LIPOPHILICITY OF EIGHT NEW<i>P-</i>TOLUENESULFONYL-HYDRAZINOTHIAZOLE AND HYDRAZINE-BIS-THIAZOLE DERIVATIVES: A COMPARISON BETWEEN RP-HPTLC AND RP-HPLC
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Abstract Using RP-HPTLC and RP-HPLC and a methanol-water mixture as the mobile phase, eight new p-toluenesulfonyl-hydrazinothiazole and hydrazine-bis-thiazole derivatives were studied. The linear correlation between RMw, kW and methanol/water ratios showed high values, for the correlation coefficient R2. The chromatographic hydrophobic index ϕ0 was determined by using intercept and slope, the obtained values ranging between 60 and 98. A good linear correlation was obtained between RMw, log kw, and slope. The log P values were calculated using database (Toronto, Canada). The matrices were formed with RMw, log kw and log P and were subjected to principal component analysis (PCA). The best way to extract information from PCA was graphically, by plotting the obtained matrices. By analyzing the scores, the compounds can be grouped in two: the first group contains three compounds that have a phenyl moiety while the second group comprises other five compounds that contain: methyl, chlor-methyl, acetyl, and ethylic ester. Keywords: Computed Log P8 new compoundshydrophobiclypophilicPCARP-HPTLC and RP-HPLC
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.002 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it