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Record W2004429375 · doi:10.1038/ng.2560

Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array

2013· article· en· W2004429375 on OpenAlexaff
Rosalind A. Eeles, Ali Amin Al Olama, Sara Benlloch, Edward J. Saunders, Daniel Leongamornlert, Malgorzata Tymrakiewicz, Maya Ghoussaini, Craig Luccarini, Joe Dennis, Sarah Jugurnauth-Little, Tokhir Dadaev, David E. Neal, Freddie C. Hamdy, Jenny Donovan, Ken Muir, Graham G. Giles, Gianluca Severi, Fredrik Wiklund, Henrik Grönberg, Christopher A. Haiman, Fredrick R. Schumacher, Brian E. Henderson, Loı̈c Le Marchand, Sara Lindström, Peter Kraft, David J. Hunter, Susan M. Gapstur, Stephen J. Chanock, Sonja I. Berndt, Demetrius Albanes, Gerald L. Andriole, Johanna Schleutker, Maren Weischer, Federico Canzian, Elio Ríboli, Timothy J. Key, Ruth C. Travis, Daniele Campa, Sue A. Ingles, Esther M. John, Richard B. Hayes, Paul D.P. Pharoah, Nora Pashayan, Kay‐Tee Khaw, Janet L. Stanford, Elaine A. Ostrander, Lisa B. Signorello, Stephen N. Thibodeau, Dan Schaid, Christiane Maier, Walther Vogel, Adam S. Kibel, Cezary Cybulski, Jan Lubiński, Lisa Cannon‐Albright, Hermann Brenner, Jong Y. Park, Radka Kaneva, Jyotsna Batra, Amanda B. Spurdle, Judith A. Clements, Manuel R. Teixeira, Ed Dicks, Andrew Lee, Alison M. Dunning, Caroline Baynes, Don Conroy, Melanie Maranian, Shahana Ahmed, Koveela Govindasami, Michelle Guy, Rosemary Wilkinson, Emma Sawyer, Angela Morgan, David P. Dearnaley, Alan Horwich, Robert Huddart, Vincent Khoo, Christopher Parker, Nicholas van As, Christopher Woodhouse, Alan Thompson, Tim Dudderidge, Chris Ogden, Colin S. Cooper, Artitaya Lophatananon, Angela Cox, Melissa C. Southey, John L. Hopper, Dallas R. English, Markus Aly, Jan Adolfsson, Jiangfeng Xu, Siqun L. Zheng, Meredith Yeager, Rudolf Kaaks, W. Ryan Diver, Mia M. Gaudet, Mariana C. Stern, Román Corral, Amit D. Joshi, Ahva Shahabi, Tiina Wahlfors, Teuvo L.J. Tammela, Anssi Auvinen, Jarmo Virtamo, Peter Klarskov, Børge G. Nordestgaard, Martin Andreas Røder, Sune F. Nielsen, Stig E. Bojesen, Afshan Siddiq, Liesel M. FitzGerald, Suzanne Kolb, Erika M. Kwon, Danielle M. Karyadi, William J. Blot, Wei Zheng, Qiuyin Cai, Shannon K. McDonnell, Antje E. Rinckleb, Bettina F. Drake, Graham A. Colditz, Dominika Wokołorczyk, Robert A. Stephenson, Craig C. Teerlink, Heiko Müller, Dietrich Rothenbacher, Thomas A. Sellers, Hui‐Yi Lin, Chavdar Slavov, Vanio Mitev, Felicity Lose, Srilakshmi Srinivasan, Sofia Maia, Paula Paulo, Ethan M. Lange, Kathleen A. Cooney, Antonis C. Antoniou, Daniel Vincent, François Bacot, Daniel C. Tessier, Zsofia Kote‐Jarai, Douglas F. Easton

Bibliographic record

VenueNature Genetics · 2013
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicEpigenetics and DNA Methylation
Canadian institutionsMcGill University and Génome Québec Innovation Centre
FundersNational Center for Advancing Translational SciencesNational Institute of General Medical SciencesNational Cancer InstituteCancer Research UKProstate Cancer UKNational Institutes of HealthChina Scholarship CouncilNational Institute for Health and Care Research
KeywordsBiologyGenotypingIdentification (biology)Prostate cancerGeneticsComputational biologyCancerGenotypeGene

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.005
Threshold uncertainty score0.015

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0020.002
Science and technology studies0.0010.000
Scholarly communication0.0010.000
Open science0.0010.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0040.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.012
GPT teacher head0.291
Teacher spread0.279 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations550
Published2013
Admission routes1
Has abstractno

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