Design and Synthesis of Novel Phenothiazinium Photosensitiser Derivatives
Bibliographic record
Abstract
Abstract A high‐yielding approach towards N ‐(2‐aminoethyl)‐Azure B has been established and extended towards the preparation of a functionalized peptide‐dye synthetic precursor; Boc‐protected 3‐(alkylamino)phenothiazin‐5‐ium TFA. This has been utilized in a series of reactions with various amines towards nine novel 3,7‐disubstituted phenothiazin‐5‐ium derivatives. Cleavage of the Boc group in the 3,7‐disubstituted salts allowed a further seven novel dyes to be prepared and these have been utilized in a practical methodology designed for the synthesis of 13 novel phenothiazine‐peptide conjugates. These peptide‐photosensitizer vectors consist of a covalent attachment of a tethered dye to various protected amino acid moieties including the cell‐penetrating peptide (CPP) octa‐arginine and exhibit intense absorption maxima in the 623–650 nm regions of the visible spectrum. The main goal of the studies is the design of cell‐compatible photosensitisers that may be employed in photodynamic therapy.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".