Risperidone for Individuals with Refractory Schizophrenia
Bibliographic record
Abstract
Background Risperidone has been shown to be as effective as other atypical antipsychotic medications in the treatment of psychotic symptoms, but its effectiveness in refractory psychotic symptoms is unclear. Objective In this paper, we aim to review the available evidence related to the use of risperidone in refractory schizophrenia. Methods English language articles ranging from 1985 to 2009 (inclusive) were retrieved from Pubmed in December 2009 using the search terms ‘schizophrenia’, ‘refractory’, ‘resistant’, ‘risperidone’, ‘atypical’, ‘combination’ and ‘antipsychotic’. Results The available literature is conflicting on the use of risperidone as an augmentation of clozapine or of other antipsychotics and methodological problems make drawing firm conclusions difficult. Studies using Risperidone Long Acting Injection have included both individuals with recent-onset schizophrenia and those with refractory schizophrenia, whch makes it difficult to interpret its effectiveness specifically for those with refractory schizophrenia. Risperidone may reduce potentially disabling cognitive symptoms of schizophrenia, but these effects do not differ significantly from that of other typical and atypical antipsychotic medications. Conclusion Further and more rigorous research is required on risperidone for refractory schizophrenia.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".