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Pharmacokinetic-Pharmacodynamic Consequences and Clinical Relevance of Cytochrome P450 3A4 Inhibition

2000· review· en· 907 citations· W2005328285 on OpenAlex· 10.2165/00003088-200038010-00003

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

Canadian affiliationAn author listed a Canadian institution. This is the only route the usual frame has.

Machine scores (provisional)

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Opus teacher head0.291
GPT teacher head0.570
Teacher spread
0.279 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Abstract

No abstract. This is not a gap in this database — OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

The record

Venue
Clinical Pharmacokinetics
Topic
Pharmacogenetics and Drug Metabolism
Field
Pharmacology, Toxicology and Pharmaceutics
Canadian institutions
London Health Sciences CentreWestern University
Funders
Keywords
PharmacologyDrug interactionRitonavirCYP3A4KetoconazoleTriazolamPharmacokineticsDextromethorphanMedicineChemistryBenzodiazepineCytochrome P450Internal medicine
Has abstract in OpenAlex
no