Exercise-Induced Improvement in Insulin Sensitivity Is Not Mediated by Change in Cardiorespiratory Fitness
Bibliographic record
Abstract
Although exercise-induced improvement in cardiorespiratory fitness (CRF) and reduction in abdominal obesity are putative mechanisms by which chronic exercise attenuates insulin resistance (1), the independent contribution of each is unknown. We therefore investigated whether improvement in abdominal obesity and/or CRF mediates the effect of exercise on insulin sensitivity in abdominally obese adults. Participants included sedentary, abdominally obese men and women who participated in two previously published exercise interventions (2,3). Participants were randomized to control ( n = 18) or supervised aerobic exercise ( n = 59) for 3 (women) or 4 (men) months. CRF (VO2peak) was measured using a maximal treadmill test, abdominal obesity by magnetic resonance imaging and waist circumference (WC), and insulin sensitivity by the hyperinsulinemic-euglycemic clamp. Simple mediation analysis (Table 1) revealed that with the exception of …
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.003 | 0.001 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.002 | 0.002 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".