Meta-analysis of correlates of HPV vaccine acceptability among men: supporting vaccine implementation science
Bibliographic record
Abstract
Understanding ubiquitous research-to-practice gaps in uptake of adult vaccines, particularly those for sexually transmitted infections (e.g., suboptimal human papillomavirus [HPV] vaccine uptake among men in the US), may provide evidence to support the successful dissemination of future HIV vaccines. To this end, we assessed rates of HPV vaccine acceptability and factors correlated with HPV vaccine acceptability among men. We used a comprehensive search strategy across multiple electronic databases to locate studies that examined rates and/or correlates of HPV vaccine acceptability. The search strategy had no date or language restrictions. Search keywords included vaccine, acceptability and all terms for human papillomavirus. We calculated mean HPV vaccine acceptability scores across studies. We conducted meta-analysis using a random effects model on cross-sectional studies reporting correlates of HPV vaccine acceptability. All studies were assessed for risk of bias. Of 301 identified studies, 22 met inclusion criteria. Across 18 studies (n=7787), weighted mean HPV vaccine acceptability = 52.3 (SD 17.5) (100-point scale). HPV vaccine acceptability was significantly higher among gay/bisexual/MSM (65.1, SD 15.1) versus heterosexual men (47.3, SD 14.7). Among 11 studies (n=4064) included in meta-analyses, perceived HPV vaccine benefits and doctor recommendation had medium effect sizes, and the following factors had small effect sizes on HPV vaccine acceptability: anticipatory regret, perceived effectiveness, fear of side effects, perceived partner support for vaccination, perceived susceptibility to HPV, number of lifetime sexual partners, having a current sex partner, Hepatitis B vaccine uptake, smoking cigarettes, HPV awareness, knowledge and non-white ethnicity. Public health campaigns tailored for men that promote positive HPV vaccine attitudes, HPV knowledge and risk awareness, and healthcare provider education, may support HPV vaccine acceptability for men; these factors may be instructive in planning for future HIV vaccine dissemination. Future investigations employing rigorous designs, including intervention studies, are needed to support effective vaccine promotion among men.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.004 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.002 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.019 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".