Biomechanical responses after Wingspan Stent deployment in swine ascending pharyngeal artery
Why this work is in the frame
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Bibliographic record
Abstract
OBJECTIVES: Symptomatic intracranial atherosclerotic stenosis is associated with a high rate of recurrent stroke. Endovascular angioplasty and stenting using the Wingspan(TM) Stent (Stryker) has been used for treatment of this disorder. However, a recent randomized trial (SAMMPRIS Clinical Trial) reported that it was inferior to aggressive medical management. To explore the cause of stroke complications after treatment with the Wingspan Stent, we simulated the biomechanical responses in a swine ascending pharyngeal artery (APA) using the finite element method. METHODS: A Wingspan Stent was deployed in a swine APA, and simulated stress distributions including radial, circumferential, and wall shear stress were evaluated. Histopathological analysis of the selected APA was made 28 days post-stenting. RESULTS: We detected increased radial stress concentration at distal stent markers with a stent edge and a graded augmentation of radial stress from proximal to distal. There was an impaired wall shear stress near the stent struts and stent markers. Intense neointimal hyperplasia was observed from the middle to distal segment of the stent 28 days after the procedure. DISCUSSION: This preliminary data suggest that the Wingspan Stent produces increased radial stress distribution with distal segment in a tapering artery. It is possible that the radial stress concentration plays a role in the development of neointimal hyperplasia.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it