797 DUTASTERIDE REDUCES PROSTATITIS SYMPTOMS COMPARED TO PLACEBO IN MEN ENROLLED IN THE REDUCE (REDUCTION BY DUTASTERIDE OF PROSTATE CANCER EVENTS) STUDY

You have accessJournal of UrologyInfections/Inflammation of the Genitourinary Tract: Prostate & Genitalia1 Apr 2010797 DUTASTERIDE REDUCES PROSTATITIS SYMPTOMS COMPARED TO PLACEBO IN MEN ENROLLED IN THE REDUCE (REDUCTION BY DUTASTERIDE OF PROSTATE CANCER EVENTS) STUDY J. Curtis Nickel, Teuvo L.J. Tammela, Claudio Teloken, Timothy H. Wilson, Ivy L. Fowler, and Roger S. Rittmaster J. Curtis NickelJ. Curtis Nickel Kingston, Canada More articles by this author , Teuvo L.J. TammelaTeuvo L.J. Tammela Tampere, Finland More articles by this author , Claudio TelokenClaudio Teloken Porto Alegre, Brazil More articles by this author , Timothy H. WilsonTimothy H. Wilson Research Triangle Park, NC More articles by this author , Ivy L. FowlerIvy L. Fowler Research Triangle Park, NC More articles by this author , and Roger S. RittmasterRoger S. Rittmaster Research Triangle Park, NC More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2010.02.1473AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES REDUCE is a completed 4-year study of prostate cancer risk reduction with dutasteride. This analysis examines the effects of dutasteride vs. placebo on prostatitis-like symptoms as measured by the Chronic Prostatitis Symptom Index (CPSI). METHODS CPSI was administered at baseline and every 6 months in men (aged ≥50 and ≤75 years, who had a serum PSA ≥2.5 and ≤10 ng/ml and negative baseline biopsy) randomized to dutasteride or placebo. Changes in total and sub scores of the CPSI from baseline were compared in patients identified with prostatitis-like pain (CPSI pain sub score ≥5) and prostatitis-like syndrome (perineal and/or ejaculatory pain + CPSI pain sub score ≥4), using a general linear model with effects for baseline score. Comparison of responders, defined as those who had at least a 4-point (at least minimal response) or 6-point (at least moderate response) decrease in total CPSI were compared using the Fisher′s Exact Test. RESULTS CPSI score was available in 2682 and 2696 men in the placebo and dutasteride groups, respectively. There were 337 (mean CPSI 15.36) and 328 (mean CPSI 14.96) men with prostatitis-like pain and 182 (mean CPSI 14.92) and 184 (mean CPSI 14.93) men with prostatitis-like syndrome identified at baseline in the placebo and dutasteride groups, respectively. There was a significant decrease in total and most sub-scores of the CPSI at 48 months in the dutasteride group compared with the placebo group (Table). In the prostatitis-like pain subgroup and prostatitis-like syndrome subgroup, there were significantly more 4-point responders (63.3% and 58.6% respectively) and 6-point responders (49.2% and 46.6% respectively) in the dutasteride groups compared with placebo groups (49.8 % and 45.4% respectively for 4-point responders; 37.5% and 32.8% respectively for 6-point responders). Table. Mean changes in Chronic Prostatitis Symptom Index (CPSI) sub-scores from baseline Mean change from baseline at Month 48 Patient groups Total CPSI CPSI Pain CPSI Urinary CPSI QoL Prostatitis-like pain Placebo -2.84 -2.93 0.37 -0.21 Dutasteride -5.35 -3.92 -0.78 -0.53 p value <0.0001 0.0008 <0.0001 0.0005 Prostatitis-like syndrome Placebo -2.47 -2.64 0.31 -0.24 Dutasteride -4.60 -3.33 -0.65 -0.46 p value 0.0031 0.0890 0.0033 0.0719 CONCLUSIONS Treatment with dutasteride over 4 years improved prostatitis-related symptoms in older men identified with prostatitis-like pain and prostatitis-like syndrome. © 2010 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 183Issue 4SApril 2010Page: e311-e312 Advertisement Copyright & Permissions© 2010 by American Urological Association Education and Research, Inc.MetricsAuthor Information J. Curtis Nickel Kingston, Canada More articles by this author Teuvo L.J. Tammela Tampere, Finland More articles by this author Claudio Teloken Porto Alegre, Brazil More articles by this author Timothy H. Wilson Research Triangle Park, NC More articles by this author Ivy L. Fowler Research Triangle Park, NC More articles by this author Roger S. Rittmaster Research Triangle Park, NC More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...

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