Pulmonary Intravascular Lymphoma
Bibliographic record
Abstract
Intravascular lymphoma (IVL) is a rare form of non-Hodgkin lymphoma characterized by proliferation of malignant lymphoid cells limited to the lumen of small vessels. Clinical manifestations are nonspecific and result from vascular obliteration and hypoxia. The disease affects primarily the skin and central nervous system, often associated with rapid systemic dissemination and aggressive clinical course if appropriate therapy is not initiated early. Involvement of the lungs, kidneys, adrenal glands, and prostate may occur. Primary pulmonary IVL is exceedingly rare. We describe a case of primary pulmonary IVL in an HIV-positive man presenting with nonspecific constitutional symptoms. High-resolution computed tomography demonstrated centrilobular nodules with ground-glass attenuation and peribronchial ground-glass opacities. The diagnosis was confirmed by thoracoscopic biopsy and histologic findings consisted of accumulation of malignant lymphocytes within alveolar capillaries, pulmonary veins, and peribronchial arterioles. Immunohistochemistry confirmed positivity for CD20, a marker for B lymphocytes. Combined systemic chemotherapy including rituximab was started and resulted in significant clinical and radiologic improvement with long-term disease-free survival.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.007 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".