Bibliographic record
Abstract
B cell DR antigens were studied with lymphocyte markers in the peripheral blood of 62 staged melanoma patients and 37 normal individuals matched for age and sex. 47 patients had early disease (31 in stage I; 16 in stage II) and 15 had advanced disease (stage III). Phagocytic cells were removed prior to testing. Specific rabbit antisera and monoclonal antibodies to purified human B cell DR and Fc molecules were used for detection of membrane immunofluorescence. Mild declines of total lymphocytes and of E-rosetting T cells were observed in comparing early to late disease. The drop of Ig(+) B cells was more striking. DR(+) cells, however, showed no change in percentage and a lesser drop in absolute numbers, suggesting an increase with advancing disease of DR(+), Ig(-) null cells, which may represent immature B cell precursors. Fc(+) cells increased markedly in 14 patients who received levamisole, with little effect on the markers. Elevations of OKT4/OKT8 ratios were seen with a relative reduction in OKT8 cells, especially in late disease. These changes in lymphocyte subpopulations may reflect imbalance between the B and T arms from deranged immune regulation caused by chronic antigenic stimulation from progressively growing tumor. In addition to T cell suppression there is B cell hyperactivity with appearance of immature forms peripherally (shift to left).
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".