In vitro and in vivo evaluation of anti-trypanosomal activity of stem bark of Ximenia americana
Bibliographic record
Abstract
The in vitro and in vivo anti-trypanosomal activity of aqueous and methanolic extracts of bark of Ximenia americana was examined in mice experimentally infected with Trypanosoma congolense . Thirty (30) healthy mice were infected with T. congolense at 104 and subsequently treated in vitro with aqueous, methanolic and DiminavetR extract at 3, 6,and 9mg/ml and in vivo with aqueous stem bark extract at 50, 100, 200 and 300mg/Kg body weight and DiminavetR at 3.5mg/kg body weight respectively. The result showed that in vitro incubation of infected blood with methanolic extract immobilized the parasites at a concentration of 9mg/ml . In vivo study also showed the aqueous extract at 50, 100, 200 and 300mg/Kg body weight were parasite free for 1,5,7 and 14 days respectively. The effect of the extract appeared to be dose dependent. The results showed that Ximenia americana had in vitro and in vivo efficacy by suppressing the growth of the parasites followed by a relapse.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".