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A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation

2005· article· en· 857 citations· W2008221746 on OpenAlex· 10.1038/nature04185

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

Canadian affiliationAn author listed a Canadian institution. This is the only route the usual frame has.

Machine scores (provisional)

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Opus teacher head0.006
GPT teacher head0.257
Teacher spread
0.250 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Abstract

No abstract. This is not a gap in this database — OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

The record

Venue
Nature
Topic
Wnt/β-catenin signaling in development and cancer
Field
Biochemistry, Genetics and Molecular Biology
Canadian institutions
Princess Margaret Cancer CentreOntario Institute for Cancer Research
Funders
National Institute of General Medical Sciences
Keywords
LRP6Wnt signaling pathwayCell biologyPhosphorylationGSK-3DKK1LRP5BiologyPhosphorylation cascadeCasein kinase 1Signal transductionChemistryBiochemistryProtein phosphorylationProtein kinase A
Has abstract in OpenAlex
no