The Effect of Endurance Training on Phosphoinositide Metabolism of Extensor Digitorum Longus in Rats
Bibliographic record
Abstract
We tested the hypothesis that endurance training results in changes in inositol triphosphate (InsP3) production from membrane phosphoinositides in trained muscles during contractile activity, which might have implications for fatigue involving calcium-release mechanisms. The extensor digitorum longus (EDL) muscles of endurance-trained rats were measured for membrane phosphoinositides, fatigability, and the production of inositol phosphates resulting from a 10-s tetanic contraction in vitro. In the latter, training resulted in a 22% increase in the production of inositol phosphates, in spite of lower phosphoinositides per muscle. In a separate group of animals, pretreatment of EDL in vitro for 15 min with 20 mM lithium resulted in a gradual decrease in tetanic forces at 100 Hz and increased fatigability. These results show for the first time that this metabolic system adapts to increased use and may contribute to the associated increased fatigue resistance, through its modulation of calcium release by sarcoplasmic reticulum.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".