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Record W2009144436 · doi:10.1038/ng1333

Assessing the impact of population stratification on genetic association studies

2004· article· en· W2009144436 on OpenAlexfundno aff
Matthew L. Freedman, David Reich, Kathryn L. Penney, Gavin J. McDonald, André A. Mignault, Stacey Gabriel, Eric J. Topol, Jordan W. Smoller, Carlos N. Pato, Michele T. Pato, Tracey L. Petryshen, Laurence N. Kolonel, Eric S. Lander, Pamela Sklar, Brian E. Henderson, Joel N. Hirschhorn, David Altshuler

Bibliographic record

VenueNature Genetics · 2004
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenetic Associations and Epidemiology
Canadian institutionsnot available
FundersCanadian Institutes of Health ResearchNational Institutes of HealthNational Alliance for Research on Schizophrenia and DepressionSystematics AssociationBristol-Myers SquibbTakeda OncologyU.S. Department of Defense
KeywordsPopulation stratificationBiologyStratification (seeds)Genetic associationPopulationCohortGenotypingAncestry-informative markerEvolutionary biologyGeneticsAlleleDemographyAllele frequencyGenotypeGeneSingle-nucleotide polymorphismInternal medicineMedicine

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.213
metaresearch head score (Gemma)0.512
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch
Consensus categoriesMetaresearch
DomainCandidate signal: Methods · Consensus signal: none
Study designCandidate signal: Simulation or modeling · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.787
Threshold uncertainty score0.970

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.2130.512
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0020.004
Bibliometrics0.0030.005
Science and technology studies0.0020.005
Scholarly communication0.0030.003
Open science0.0020.004
Research integrity0.0030.004
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.023
GPT teacher head0.379
Teacher spread0.356 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; the direct Gemma label and the distilled Codex classifier agree on what is shown here.

Study designSimulation or modeling
DomainMethods
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations822
Published2004
Admission routes1
Has abstractno

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