Carboranes as Ligands for the Preparation of Organometallic Tc and Re Radiopharmaceuticals. Synthesis of [M(CO)<sub>3</sub>(η<sup>5</sup>-2,3-C<sub>2</sub>B<sub>9</sub>H<sub>11</sub>)]<sup>-</sup> and <i>r</i><i>ac</i>-[M(CO)<sub>3</sub>(η<sup>5</sup>-2-R-2,3-C<sub>2</sub>B<sub>9</sub>H<sub>10</sub>)]<sup>-</sup> (M = Re, <sup>99</sup>Tc; R = CH<sub>2</sub>CH<sub>2</sub>CO<sub>2</sub>H) from [M(CO)<sub>3</sub>Br<sub>3</sub>]<sup>2-</sup>
Why this work is in the frame
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Bibliographic record
Abstract
A new and high yielding method for the synthesis of [M(CO)(3)(eta(5)-2,3-C(2)B(9)H(11))](-) and the bifunctional metal complexes, rac-[M(CO)(3)(eta(5)-2-R-2,3-C(2)B(9)H(10))](-) (R = CH(2)CH(2)CO(2)H), from [M(CO)(3)Br(3)](2)(-) (M = Re, (99)Tc) was developed. The general approach entailed the addition of nido-[(C(2)B(9)H(12))(-)], or the acid substituted analogue, to [M(CO)(3)Br(3)](2)(-) (M = Re, (99)Tc) in the presence of TlOEt in THF. It was also possible to prepare the reported products in water using sodium carbonate in place of TlOEt. The reported approach led to the preparation, and X-ray crystallographic structure determination, of the first Tc-carborane complex reported to date (a = 13.606(17) A, b = 10.685(13) A, c = 15.534(16) A, alpha = gamma = 90 degrees, beta = 111.84(2) degrees). Because of the stabilities of the metal complexes, and the fact that the compounds can be prepared in water, the bifunctional derivatives can be considered as novel synthons for the preparation of organometallic (99m)Tc and (186/188)Re radiopharmaceuticals.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.018 | 0.018 |
| Meta-epidemiology (narrow) | 0.029 | 0.032 |
| Meta-epidemiology (broad) | 0.029 | 0.014 |
| Bibliometrics | 0.009 | 0.022 |
| Science and technology studies | 0.011 | 0.019 |
| Scholarly communication | 0.007 | 0.012 |
| Open science | 0.019 | 0.010 |
| Research integrity | 0.022 | 0.026 |
| Insufficient payload (model declined to judge) | 0.001 | 0.005 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it